ABSTRACT
Backgrounds: Iodine deficiency disorder is a major public health problem in areas where there is a lack of iodine in drinking water, soil, and food. This study was carried out to assess the prevalence of goiter among school children in the age group of 6-10 years in Khorramabad city. Also, the level of urine iodine was evaluated
Methods: The study was conducted from January 2012 to January 2013 in 1125 school children of 6-10 years of age, attending all the schools of Khorramabad city. The subjects were selected through stratified, random, and cluster sampling methods. Their Goiter degrees were evaluated according to WHO classification. Excretory urine iodine was measured based on micrograms per deciliter. Furthermore, the digestion method was used for experimentation
Results: Out of the 1125 subjects, 866 [77%] had Goiter. 24.2% were diagnosed with Goiter 1a, 45.3% with goiter 1b, and 7.2% with type 2 Goiter. Regarding Goiter, there was no difference between the two sexes. The prevalence of goiter increased with age, but it decreased with the increase of parental educational level. Also, goiter prevalence was lower in families with a higher socioeconomic status. The median urinary iodine was 17.1 micrograms per deciliter, which is desirable in terms of the WHO criterion
Conclusion: The results of the study indicated that using iodizing edible salt to fight with iodine deficiency was effective and helped Khorramabad reach the International indexes of iodine control. Despite this, Khorramabad is one of the hyper- endemic regions in the world
ABSTRACT
A major function of the enterocytes is absorption, processing, and export of dietary lipids into the lymphatic system. Pluronic L-81 is a non-ionic hydrophobic surfactant, which specifically inhibits lipid absorption in the intestine when administered in vivo. This compound is therefore an attractive probe to perturb and investigate the molecular and intracellular events in chylomicron assembly in the enterocytes. In the present study pluronic acid was administered to hamsters followed by isolation of the enterocytes and cell fractionation to investigate the effect of pluronic acid on intracellular events in lipid absorption. Four types of diet were administered to hamsters for three weeks; low-fat chow, high-fat chow and each diet with or without added pluronic acid. Sub-cellular fractions of freshly isolated enterocytes were prepared. Consistent with morphological observation, the high fat diet resulted in a three-fold increase in the triacylglycerol [TAG] content of the enterocytes and addition of pluronic acid to either the low fat or the high fat diets resulted in a ten-fold increase in cellular TAG levels. Determination of the mass of TAG and the time course of incorporation of 3H-triolein, administered by gavage, showed that the increased TAG was recovered in the microsomal [endoplasmic reticulum] fraction and the cytosol. In microsomes, increased TAG was recovered mainly in the membrane although there was a significant amount in the microsomal luminal contents. Pluronic acid therefore acts at the level of the endoplasmic reticulum and inhibits the assembly of apo-B48 with chylomicron TAG. The excess TAG is transferred to cytosolic stores